Digital holography
helps life science leap

In the field of life science, digital holography is a technology that has changed the way analysts around the world conduct their work. Phase Holographic Imaging, a world leader in non-invasive live cell imaging, is a key factor in that development, having launched multiple generations of microscopes based on digital holography.

The development of this technology has been backed by Vinnova, the Swedish governmental agency for innovation systems.

”Our core competence lies in cell analysis which is obviously one key area to develop further,” explains Mikael Sebesta, head of research and development at Phase Holographic Imaging. ”But we also needed to develop holography and teamed up with Optronic, in order to benefit from the competence there.”

Phase Holographic Imaging’s leading product on the market, is the fourth generation of cell analysers using Holographic Imaging, the Holomonitor M4.

The key to understanding the use for digital holography lies in the term “non-invasive”. Currently, most cell imaging is carried out by using additives that affect a live sample in a way that often makes it unusable for further analysis.
“Our analysis is non-destructible of live cells, which means that reactions to drugs and modulation of gene expressions are areas where the quality of testing can be improved with digital holography,” explains Sebesta.

And there is no mistaking the market potential, as there are around 150,000 cell labs, where 650,000 scientists and analysts work, worldwide.
“That includes everything from the smallest of labs to large establishments,” says Sebesta. “For many of these analysts, being able to analyse live biological cells without destroying or affecting them in unwanted ways, is the key to conducting better studies.”